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Human Factors: Welford 1968
This experiment replicates the early studies investigating Fitts's Law, as detailed in Welford's book. It involves having participants move their mouse as quickly as possible between two vertical stripes on the screen (which vary in size and distance apart).

Fitts's Law describes the relationship of distance from current location and size to speed and accuracy. Basically, the closer and larger a target is, the easier it is to find.

For more information, see the following sites:

Usability First Glossary: Fitts's Law
Fitts's Law online experiment

Hyman 1953
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Brian MacWhinney